Liposomal Encapsulation Process For:
FECO, RSO, BHO, and Other Concentrates
Keeping in mind that FECO, RSO and even BHO can often already be extensively heat processed, we are providing the bare minimum process required to produce the least additional degradation while taking full advantage of heated liposomal encapsulation tech.
Please source organically extracted cannabis, processed using only food grade solvents, whenever possible.
Measure and prepare individual ingredients in this ratio:
1 Part FECO
2 Parts Lecithin Granules ( @ 23%+/- phosphatidyl choline)
2 Parts Coconut Oil
This will produce for every 1 gram of FECO, 5 x 00 caps, each containing 0.20g FECO; cannabinoid content and composition are reliant on original feco composition.
See below for directions.
1.) Preheat coconut oil and lecithin to 160 F.
2.) Add FECO, and manually agitate until blended sufficiently to the naked eye.
With small quantities, this can easily be done with a spoon. With larger
amounts you can make good use of a chocolate tempering machine, or
even a more expensive conching machine (if electric/heated- some are not).
3.) Heat solution to at least 215 - 220 F and hold for 30 minutes. Allow to cool.
The vessel you heat in should ideally be sealed well, but with a material
that allows for expansion with heat, effectively containing and trapping,
rather than releasnig terpenes.
4.) Freeze overnight, warm to room temp.
5.) Repeat step 3.) by heating once more, then extinguish heat source, and
allow to cool gradually avoiding sudden drops in temperature, ideally
leaving container in place and heating aparatus sealed, until solution
temperature drops to 150 F in no less than 30 minutes. (Once the oil is
cool, avoid reheating to temperatures that exceed 200 F. If for whatever
reason this occurs, repeat step 5. once again. Keep in mind most baked
goods will not reach or exceed internal temperatures of 150 F - 200 F,
by the time they have finished baking, even when your oven temperature
is set much higher.)
Your oil is now complete and may be diluted if necessary for low-tolerance dosing, inserted into capsules using a common pipette, or you may even choose to use your finished medicine prepared in a food, for patients who need assistance and/or relief during digestion. The steps must be performed exactly as described for liposomal encapsulation of cannabinoids to occur effectively. For reasoning behind steps and additional details, read the basic content found here, and google "BadKittySmiles bioavailability".
First Time Oil & Initial
Low-Dose Tolerance Building
Complete infusion, using the above mentioned ratio, by adding and blending in an additional A) 15ml coconut oil (previous cannabis users)
up to to an additional B) 35ml coconut oil (brand new patients), to the existing solution as described above, for every gram of feco the solution contains. This may be done separately with a portion of finished liposomal oil using gentle heat, so as not to dilute your entire batch, or during the second heating of the process.
A) Adding 15ml coconut oil per each gram of FECO used in the existing solution, will produce 20 x 00 size capsules from each gram of FECO, instead of 5 x 00 caps. Each individual capsule will have a total feco content of 0.05g or 50mg.
If you used 2 grams of FECO, you would need to add 30ml coconut oil to the existing 10ml solution. If you used 4 grams of FECO, you would need to add 60ml oil to the existing 20ml solution.
B) Adding 35ml coconut oil per gram of FECO in the solution, will produce 40 x 00 size capsules from each gram of FECO, instead of 5 x 00 caps. Each individual capsule will have a total feco content of 0.025g or 25mg.
If you used 2 grams of FECO, you would need to add 70ml coconut oil to the existing 10ml solution. *
* We do not suggest diluting any more than 2g FECO at the rate suggested in part B), unless this is simply the desired dose for long-term treatment of a non-serious/non-life threatening condition; for serious conditions where time is of the essence, you should increase your tolerance adequately, almost daily, prior to finishing a batch of this size, rendering such a rate of dilution much less useful for your condition.
In terms of cancer, the rate of dilution suggested in B) is for the purposes of rapidly increasing tolerance only.
Even prevention and maintenance doses upon succesful remission, should remain as high as 0.25g/concentrate each day.
Tolerance Building Program
The tolerance building program below should begin with the DILUTED formula, found on the Liposomal Encapsulation page, that is best suited to the patient's recent history with cannabis use.
1.) The first dose or capsule should be taken within an hour before the patient's normal bedtime.
Should there be any uncomfortable sensations from an initial dose, or a dose that is too large, the patient will still be able to benefit from the medicine, while sleeping through any unwanted side effects.
Avoiding tolerance scares is crucial to increasing the dose, and building a tolerance rapidly; a single eposide of discomfort during early treatment, can dramatically decrease the patient's desire (consciously or otherwise) to continue with the treatment, and memories of the discomfort can resurface causing unwanted stress upon subsequent or following doses, hindering your progress and the ultimate goal, of taking more oil at a rapid pace. As the body detoxifies, heals and purges unwanted elements, the processing of healing can be uncomfortable enough as it is.
If you are a caregiver, please prepare your patient for this inevitability: the treatment itself can potentially cause discomfort when it is overdone, but healing serious illnesses and imbalances, and regenerating healthy tissue somewhat like "growing pains", can also almost certainly cause strange and unwanted sensations.
2.) When the patient awakens that first morning, if they do not feel any overly strong sensations beyond a slight sense of lethargy, have them go about their normal business during most of the day, then have them dose again, but this time three to four hours before bed. This time, have them document how they feel just before getting into bed.
2a.) If the patient awakens and feels noticeable medicated, have them continue their day as normal, and repeat the same dosing procedure until morning sensations diminish - eg. normally 4 - 6 days. Then, have the patient beging taking their evening dose 3 to 4 hours before bed. Have the patient chart their feelings and any sensations as the medicine begins to take effect.
3.) If the patient was relatively comfortable before going to bed, and felt that the dose left them reasonably functional, the following day they may begin a secondary dose in the early afternoon IN ADDITION to their night time dose.
4.) If the patient is still comfortable 24hrs after adding a second daily dose, then as soon as possible, have them add a second capsule to their night time dose, bringing them to 3 a day.
At this point, the patient should begin feeling confidant in increasing the dose. Always remind them that, in spite of how hard many scientists and recreational cannabis users have tried, no one has ever achieved a toxic dose of concentrated cannabis in their system. Sensations may be uncomfortable, but with calm presence of mind, you will get through and interally, your body will almost certainly be better for it in the long run.
From this point onward, with the remainder of your starter caps, continue to increase by adding capsules in this order, two in the evening, one in the afternoon, every day that you feel comfortable doing so, until they run out.
With your future capsules, you
Other Areas Of Interest : Calculating Contents,
The original concentrated base blend, will produce capsules 0.20g,
or 200mg FECO in strength.
This is NOT indicative of the total cannabinoid content, only the RSO/FECO/BHO content.
In order to calculate cannabinoid content accurately in the final solution, you must have had prior knowledge of the actual cannabinoid content of the starting material.
If that is the case, then by taking into consideration the ratios used, a little simple math can help you to determine the contents of each ml of the solution, with a good degree of accuracy.
1) Using the original formula strength, if your starting FECO/RSO had a THC content of 67% and CBD content of 4.5%, then the 5 (five) finished 00 size capsules created from one gram of FECO, will contain 13.4% THC and 0.9%CBD.
In mg's this translates to 134mg THC and 9mg CBD.
2) Using the Low-Dose formula 'A' strength, if your starting FECO/RSO had a THC content of 67% and CBD content of 4.5%, then the 20 (twenty) finished 00 size capsules, created from one gram of FECO, will contain 3.35% THC and 0.23%CBD.
In mg's this translates to 33.5mg THC and 2.3mg CBD.
3) Using the Low-Dose formula 'B' strength, if your starting FECO/RSO had a THC content of 67% and CBD content of 4.5%, then the 40 (forty) finished 00 size capsules, created from one gram of FECO, will contain 1.68% THC and 0.113%CBD.
In mg's this translates to 16.8mg THC and 1.13mg CBD.
We suggest that patients use a smaller capsule size than 00 for their first four days, or simply fill the caps no more than half way to begin.
Keep in mind 00 capsules are considered to hold .95ml, not 1ml, meaning that "in reality" your 1 gram of FECO, diluted to 20 Caps according to the directions, will technically be dispersed between 21 capsules; this is because each cap leaves behind 0.05ml, that multiplied by 20 capsules, leaves enough oil to fill one capsule with a remainder of .05ml. When divided according to 40 x 00 caps, the total number of capsules containing a single gram, will be closer to 42.
The calculations in the three examples above for volume/ml alone are accurate, however the rate suggested in the paragraph immediately above, would be the most appropriate to use when calculating contents of capsules for patients. The few fractions of a ml either way may be termed in similar fashion used by both the food and pharmacetucial industry, as "acceptable deviation"
or an "allowable variance".
This term refers to the legally acceptable amount of variation in actual contents that can still often occurr, when a recipe is recreated to the best of the maker's ability.
This is used by our food and drug industry when calculating the nutritional contents in a food item, and when calculating the contents of therapeutic agents or drugs in a pill or other standardized dose. The margin for error allowed is greater for the food industry, than it is for pharmaceuticals however, because with animal and plant life especially, fat contents can fluctuate, the protein, carbohydrates, sodium content, it can all fluctuate naturally from one batch of starting ingredients to the next, and rather than ruin the finished food product by testing, then magically removing everything in excess, and supplementing the subdued components after the fact with the appropriate ratios to meet the facts on their box, which in some regions of the world with strict rules on natural food production, is not even legal, and to avoid the alternative of printing new nutrition labels with every batch cooked, they are allowed an "acceptable deviation".
If you were to screen your food and send it in for lab analysis, you'd find that in the cannabis community, while the average patient may not quite reach a pharmaceutical level of accuracy, even the newest of oil makers can be capable of doing a much better job when it comes to determining the contents of their medibles accurately, even from home, just given a little information on the contents of their starting material, than our food industry is expected to do!
There are many reasons that virtually undetectable, but potentially testable variation can occur from one batch of oil to the next; some include humidity and temperature of the workspace which can slightly effect the volume of the solution that can be closed in a capsule and alter its nature to cling to surfaces. Using silicone scraping spatulas can help you to collact all your precious oil into one "corner" of your vessel for easy siphoning with your pipette or syringe.
" But I heard more is better, doesn’t a concentrated pill have more medicine in it? "
This is true in the obvious way, in that, by adding agents like medium chain triglycerides and lecithin to a chemical to increase the oral and topical or transfdermal availability of that chemical, by nature, you are reducing the overall contents or percentage of the components. This much is true.
However, if you are increasing your absorption five or tenfold, you are effectively multiplying and creating that many more doses from the same material.
That's a ton of resources saved for the growing caregiver, and an even greater deal of money saved by the paying patient.
When more of the active components of your medicine can reach your bloodstream, instead of your toilet, and where encapsulated cannabinoids bind with much greater efficiency to target areas and receptors within the body, you not only require a smaller intake to provide much greater relief, you really NEED to take a smaller dose especially to begin with, in order to avoid any potentially uncomfortable sensations brought on by a low tolerance, and the response of your unsuspectng bodily system.
Resulting oil may be taken throughout day as needed; suggested dosage instructions – 1 – 2 caps in AM depending on needed morning symptom control, 1 – 2 caps taken in the mid afternoon, 2 – 3 caps taken in the evening, reduce or take additional caps as needed, with cancers working towards heavier evening or late afternoon dosing as comfort level and tolerance, increases.
This course seems to have the most effect with cancer patients, encouraging lots of late night rest and promoting healthy circadian rhythms, along with the right diet and phyto-endocannabinoid support.